Ellen Dorinda Shelley was named after her mother Ellen (Shattuck) Loeffel who was a physician at a time when few women went to medical school. Dr. Shelley grew up in St. Louis and graduated from the John Burroughs School before attending Mount Holyoke College where she graduated with a degree in Zoology. She spent post-doctoral time at Stanford after completing her medical studies and dermatology training at the University of Missouri.

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